Component of natural apple peels found to help prevent muscle weakness
Search for an effective way to prevent damage to the muscles that come with disease and aging, and is located on a natural compound, the researchers very promising.
Results published in the June issue of the cellular metabolism (Cell Press publication), and to identify a natural component of apple peels known as acid as a treatment for promising newnutritional for the case of large-scale and debilitating that affect almost everyone at one time or another.
"Muscle wasting is a frequent companion of disease and aging," explained researchers from the University of Iowa, Iowa City. "Prolongs hospitalization, delays refunds, and in some cases prevents people from going to the house. Not well understood and there's no cure for it."
The research team examined the first in what happens to the activity of genes in muscle under conditions that promote poor. Turned those studies, up 63 genes that change in response to fasting in both mice and people and 29 last turn expressed in all muscles of fasting and those who suffer from spinal cord injuries. Led the comparison between these two gene expression signatures to sign the cells treated with bioactive molecules more than 1,300 small acid them اليروليك compound with effects that may resist those of atrophy.
"اليروليك acid is a natural compound interesting," they said. "It's part of a normal diet as a component of apple peels, and they always say that an apple a day keeps the doctor away ..."
The researchers gave the next acid اليروليك subjects fasted laboratory. Those experiments showed that can protect acid اليروليك against the muscles weaken as expected. Grown their muscles when addition اليروليك acid on regular food topics for weeks. And track these effects again to insulin signals in the muscles and promote corrections in gene signatures associated with atrophy.
Subjects given اليروليك acid also became smaller and had lower levels of cholesterol and blood glucose and triglycerides. The results indicate that that اليروليك acid may be responsible for some of the public benefits of eating healthy food.
"We know if you eat a balanced diet like my mother told us to eat you get this material," the researchers explained, "People who eat fast food do not get this."
It is not yet clear whether the results will translate to human patients, but the goal now is to "see if this can help people." If so, they do not know yet whether اليروليك acid levels that can be consumed as part of a normal diet may or may not be enough.
Journal reference:
MRNA expression signatures for Human Rights skeletal muscle atrophy identify a natural compound that increases muscle cell metabolism Mass.
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